• 理性设计近红外二区（NIR-II）可激发且内质网靶向的分子光诊疗剂用于三阴性乳腺癌成像引导的增强光免疫治疗

  为解决三阴性乳腺癌（TNBC）治疗难题，研究人员设计 NIR-II 光诊疗剂，有效抑制 TNBC 肿瘤生长和转移。

  来源：Journal of Nanobiotechnology 10.6

  时间：2025-03-23

• 近3年代表性论文

  </colgroup>论文标题 作者 期刊名称 发表年限 Structures and activation mechanism of the Gabija anti-phage system Jing Li#, Rui Cheng#, Zhiming Wang#, Wuliu Yuan, Jun Xiao, Xinyuan Zhao, Xinran Du, Shiyu Xia, Lianrong Wang, Bin Zhu*, Longfei Wang* Nature 2024 Trinity strategy: enabling perovskite as hydrophilic and efficient fluorescent nanozyme for constructing biomarker reporting platform Shuo Wang; Zhongyu Wei; Qi Xu; Long Yu*; Yuxiu Xiao* ACS Nano 2024 Spatiotemporally responsive cascade bilayer microneedles integrating local glucose depletion and sustained nitric oxide release for accelerated diabetic wound healing Yongnian Zeng#, Chenyuan Wang#, Jiapeng Lei, Xue Jiang, Kai Lei, Yinli Jin, Tianshu Hao, Wen Zhang, Jianying Huang*, Wei Li* Acta Pharmaceutica Sinica B 2024 Sulfation of chondroitin and bile acids converges to antagonize Wnt/β-catenin signaling and inhibit APC deficiency-induced gut tumorigenesis. Pengfei Xu#*, Yue Xi#, Jong-Won Kim, Junjie Zhu, Min Zhang, Meishu Xu, Songrong Ren, Da Yang, Xiaochao Ma , Wen Xie* Acta Pharmaceutica Sinica B 2024 Drug-Free “Triboelectric Immunotherapy” Activating Immunity for Osteomyelitis Treatment and Recurrence Prevention Ying Yuan,# Haimei Li,# Yuchen Song, Dong Zhang, Zheng Wang, Xinzeyu Yi, Baiwen Qi, Xianzheng Zhang, Peng Jiang,* Aixi Yu* Advanced Materials 2024 Enhancing deep-seated melanoma therapy through wearable self-powered microneedle patch Chenyuan Wang#, Guangqin He#, Huanhuan Zhao#, Yun Lu, Peng Jiang,* Wei Li* Advanced Materials 2024 Plasmonic Supramolecular Nanozyme-Based Bio-Cockleburs for Synergistic Therapy of Infected Diabetic Wounds Xin Wang, Xudong Qin, Yi Liu, Yutong Fang, Hao Meng, Meili Shen, Linlin Liu*, Weiwei Huan*, Jian Tian*, Ying-Wei Yang* Advanced Materials 2024 Recent Progress in Implantable Drug Delivery Systems Guang-Qin He,# Haimei Li,# Junyi Liu, Yu-Lin Hu, Yi Liu,* Zhong Lin Wang,* Peng Jiang* Advanced Materials 2024 Endo‐ Lysosomal Network Disorder Reprograms Energy Metabolism in SorL1 ‐ Null Rat Hippocampus. &nbsp; Yajie Wang, Yuting Yang, Ying Cai, Ayikaimaier Aobulikasimu, Yuexin Wang, Chuanwei Hu, Zhikang Miao, Yue Shao, Mengna Zhao, Yue Hu, Chang Xu, Xinjun Chen， Zhiqiang Li, Jincao Chen, Lianrong Wang*, Shi Chen*. Advanced Science 2024 Hierarchical Self-Assembly Molecular Building Blocks as Intelligent Nanoplatforms for Ovarian Cancer Theranostics, Shuo Li#, Qingrong Chen#, Qi Xu#, Zhongyu Wei#, Yongjin Shen, Hua Wang, Hongbing Cai, Meijia Gu*, Yuxiu Xiao* Advanced Science 2024 The Compromised Fanconi Anemia Pathway in Prelamin A-Expressing Cells Contributes to Replication Stress-Induced Genomic Instability. &nbsp; Pengqing Nie, Cheng Zhang, Fengyi Wu, Shi Chen,* Lianrong Wang*. Advanced Science 2024 Hierarchical Self‐Assembly Molecular Building Blocks as Intelligent Nanoplatforms for Ovarian Cancer Theranostics Shuo Li#; Qingrong Chen#; Qi Xu#; Zhongyu Wei#; Yongjin Shen; Hua Wang; Hongbing Cai*; Meijia Gu*; Yuxiu Xiao* Advanced Science 2024 Complexity made easy: Aggregation-induced emission small molecules for cancer diagnosis and phototherapies. Luojia Chen#, Si-Ling Chen#, Yuncong Yuan#, Xiang Leng, Xiaoyu Xu, Jingyuan Chen, Jiayi Shi, Kun Qian, Yuanlong Xie*, Qihang Ding*, Zhen Cheng*, Meijia Gu* Aggregate 2024 Near-infrared activatable copper nanoplatforms synergize with the 5-azacytidine prodrug to potentiate cuproptosis. Shuo Wang†, Yishen Liu†, Mengya Su†, Yuanyuan Wang, Wenda Wang, Wuyin Wang, Qichao Yang, Zhiyun Zhang, Xuechuan Hong, Zhijun Sun*, Yuling Xiao* Angew. Chem. Int. Ed. 2024 Accelerated infected wound healing by probiotic-based living microneedles with long-acting antibacterial effect Yinli Jin#, Yun Lu#, Xue Jiang#, Min Wang, Yaqi Yuan, Yongnian Zeng, Liang Guo*, Wei Li* Bioactive Materials 2024 Enhancing CAR-T Cell Therapy Against Solid Tumor by Drug-Free Triboelectric Immunotherapy Haimei Li, Zichen Wang, Yulin Hu, Guangqin He, Liang Huang, Yi Liu,* Zhong Lin Wang,* Peng Jiang* Biomaterials 2024 Molecular imaging-guided diagnosis and treatment integration for brain diseases Donghu Yu#, Menghao Liu#, Qihang Ding#, Youxian Wu, Tianqing Wang, Litong Song, Xiaoyu Li, Kun Qian, Zhen Cheng*, Meijia Gu*, Zhiqiang Li* Biomaterials 2024 Diverse interactions between AIEgens and biomolecules/organisms: Advancing from strategic design to precision theranostics Ding Qihang#, Xiaoyu Xu#, Yang Li#, Baoping Li, Qimanguli Saiding, Meijia Gu*, Wei Tao*, Ben Zhong Tang*, Jong Seung Kim* Chem 2024 De Novo siRNA nanoplatform with NIR-II imaging for treatment of carotid atherosclerotic plaques Jialu Gao† , Hua Zhu† , Huanhuan Cai†, Qihang Ding †, Xiaoxing Xiong †, Tong Zhang &nbsp;, Bo Chen , Wumei Wang , Xinpeng Ju, Jianying Huang, Xiaodong Zeng, Jong Seung Kim*, Xuechuan Hong * Chemical Engineering Journal 2024 Red blood cell membrane biomimetic nanoprobes for ratiometric imaging of reactive oxygen species level in atherosclerosis Bo Liu, Gui-Mei Han, Dong-Xia Wang, Ding-Bin Liu, An-An Liu, Jing Wang*, Yu-Ling Xiao*, Lin Yuan, De-Ming Kong* Chemical Engineering Journal 2024 Ultrasound-responsive metal-organic framework-based nanosystem for sonodynamic therapy/amplified ferroptosis/IDO-blockade osteosarcoma immunotherapy Qingjian Lei# , Wei Zhou # , Shijie Gao # , Ningxiang Sun, Bo Wang, Haixia Yang, Jie Wang, Yu Zhao, Qing Chen, Jian Tian*, Lin Cai*, Feifei Yan* Chemical Engineering Journal 2024 Mitochondria-targeted fluorophore: State of the art and future trends Qihang Ding#, Xinyu Wang#, Yan Luo#, Xiang Leng, Xin Li*, Meijia Gu*, Jong Seung Kim* Coordination Chemistry Reviews 2024 Study on antioxidant and antidiabetic components of Cirsium setosum based on molecular networking Wenhao Zhou, Huixian Chen, Yinghan Tian, Jiachuan Lei, Jianqing Yu* Food Bioscience 2024 Prenatal Amoxicillin Exposure Induces Depressive-Like Behavior in Offspring via Gut Microbiota and Myristic Acid-Mediated Modulation of the STING Pathway Wei Liyi#, Qi Cuiping#, Wang Tingting, Jin Xiuping, Zhou Xinli, Luo Mingcui, Lu Mengxi, Chen Huijun, Guo Juanjuan, Wang Hui*, Xu Dan* Journal of hazardous materials 2024 Free Radicals Generated in Perfluorocarbon−Water (Liquid−Liquid) Interfacial Contact Electrification and Their Application in Cancer Therapy Haimei Li, Zichen Wang, Xu Chu, Yi Zhao, Guangqin He, Yulin Hu, Yi Liu,* Zhong Lin Wang,* Peng Jiang* Journal of the American Chemical Society 2024 Gene-Directed In Vitro Mining Uncovers the Insect-Repellent Constituent from Mugwort (Artemisia argyi) Yao Zhi#, Chong Dai#, Xueting Fang, Xiaochun Xiao, Hui Lu, Fangfang Chen, Rong Chen, Weihua Ma, Zixin Deng , Li Lu*, Tiangang Liu* Journal of the American Chemical Society 2024 Nickel-Catalyzed Electrophiles-Controlled Enantioselective Reductive Arylative Cyclization and Enantiospecific Reductive Alkylative Cyclization of 1,6-Enynes Wenfeng Liu#, Yunxin Xing#, Denghong Yan#, Wangqing Kong*, and Kun Shen* Nature Communications 2024 Structural basis of antiphage immunity generated by a prokaryotic Argonaute-associated SPARSA system. 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Nature Microbiology 2024 Phage defence system CBASS is regulated by a prokaryotic E2 enzyme that imitates the ubiquitin pathway Yan Yan#, Jun Xiao#, Fengtao Huang#, Wei Xian#, Bingbing Yu, Rui Cheng, Hui Wu, Xueling Lu, Xionglue Wang, Wenjing Huang, Jing Li, Greater Kayode Oyejobi, Carol V Robinson, Hao Wu, Di Wu*, Xiaoyun Liu*, Longfei Wang*, Bin Zhu* Nature Microbiology 2024 Molecular basis of the phosphorothioation-sensing antiphage defense system IscS–DndBCDE–DndI. Yaqian Tang , Dan Wu, &nbsp;Yueying Zhang, &nbsp;Xuan Liu , &nbsp;Hui Chu, &nbsp;Qian Tan, Lixu Jiang, Shi Chen* , Geng Wu* and Lianrong Wang*. 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Sin. B, 2023 Discovery of novel covalent selective estrogen receptor degraders against endocrine[1]resistant breast cancer Yubo Wang # Jian Min, # Xiangping Deng, # Tian Feng, # Hebing Hu, Xinyi Guo, Yan Cheng, Baohua Xie, Yu Yang, Chun-Chi Chen, Rey-Ting Guo*, Chune Dong*, Hai-Bing Zhou* Acta Pharm. Sin. B, 2023 Tunable Fluorescent Artificial Receptor Biosensor Based on Programmable Lanthanide Metal-Organic Framework for Highly Selective Neurotransmitter Detection Long Yu#, Lixiang Feng#, Zhongyu Wei, Shuo Wang, Yumin Feng, Yongjin Shen, Junlong Cai, Jianyuan Wu*, and Yuxiu Xiao* Advanced Functional Materials 2023 Exploring the Application and Prospects of Synthetic Biology in Engineered Living Materials Qiwen Wang, Zhehui Hu, Zhixuan Li, Tiangang Liu,* and Guangkai Bian* Advanced Materials 2023 Engineered Phage with Aggregation-Induced Emission Photosensitizer in Cocktail Therapy against Sepsis Ming-Yu Wu#, Luojia Chen, Qingrong Chen, Rui Hu, Xiaoyu Xu, Yifei Wang, Jie Li, Shun Feng, Changjiang Dong, Xiao-Lian Zhang, Zhiqiang Li, Lianrong Wang*, Shi Chen*, Meijia Gu* Advanced Materials 2023 Stimuli-responsive nanotechnology for RNA delivery, Hui Zhou, Dean Shuailin Chen, Caleb J. 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Ed. 2023 A self-monitoring microneedle patch for light-controlled synergistic treatment of melanoma Chenyuan Wang#, Yongnian Zeng#, Kai-Feng Chen, Jiawei Lin, Qianqian Yuan, Xue Jiang, Gaosong Wu, Fubing Wang*, Yong-Guang Jia*, Wei Li* Bioactive Materials 2023 Tailoring albumin-based theranostic PROTACs nanoparticles for enhanced NIR-II bioimaging and synergistic cancer chemo-phototherapy Zhuang Hu# , Ruihan Li, Xinyue Cui, Changjun Hu, Zilin Chen* Chemical Engineering&nbsp; Journal 2023 Supramolecular nanovesicles with in-situ switchable photothermal/photodynamic effects for precisely controllable cancer phototherapy Liefeng Hu#, Yu Xu#, Yu Zhao, Zijie Mei*, Chuxiao Xiong, Jiaying Xiao*, Jiaxi Zhang, Jian Tian* Chemical Engineering Journal 2023 A swellable bilateral microneedle patch with core-shell structure for rapid lactate analysis and early melanoma diagnosis Huiyuan Yang#, Xue Jiang#, Yongnian Zeng, Wen Zhang, Qianqian Yuan, Meirong Yin, Gaosong Wu, Wei Li* Chemical Engineering Journal 2023 Halide salt-tuning at interface: Highly water-stable and anion-exchange-active CsPbX3@SiO2 Trimurti nanoparticles for multicolor metabolite assay Shuo Wang, Zhongyu Wei, Long Yu, Jinxuan Hou*, Gaosong Wu*, Yuxiu Xiao* Chemical Engineering Journal 2023 Triboelectric immunotherapy using electrostatic-breakdown induced direct-current Haimei Li#, Chaoyu Chen#, Zichen Wang, Yiman Huang, Guangqin He, Yi Liu*, Peng Jiang*, and Zhong Lin Wang* Materials Today 2023 Microbiota-Indole 3-Propionic Acid-Brain Axis Mediates Abnormal Synaptic Pruning of Hippocampal Microglia and Susceptibility to ASD in IUGR Offspring Wang Ting Ting#, Chen Bei Di#, Luo Ming Cui, Xie Lu Lu, Lu Meng Xi, Zhang Shuai, Wei Li Yi, Zhou Xin Li, Yao Bao Zhen, Wang Hui, Xu Dan* Microbiome 2023 The process of free radical generation in contact electrification at solid-liquid interface Yi Zhao, Yang Liu, Yuying Wang, Shulan Li, Yi Liu*, Zhong Lin Wang*, Peng Jiang* Nano Energy 2023 Insights into azalomycin F assembly-line contribute to evolution-guided polyketide synthase engineering and identification of intermodular recognition Guifa Zhai#, Yan Zhu#, Guo Sun, Fan Zhou, Yangning Sun, Zhou Hong, Chuan Dong, Peter F. 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Xiaoding Cheng#, Chong Zhang#, Kun Shen#, Huifan Liu, Caihong Bai, Qihang Ding, Mengting Guan, Junzhu Wu, Zhiquan Tian, Deliang Chen, Lin Cai*, Xuechuan Hong*, Yuling Xiao* Chemical Engineering Journal 2022 Efficient exploration of terpenoid biosynthetic gene cluster in filamentous fungi Yuan, Y.# , Cheng, S. # , Bian, G. # , Yan, P., Ma, Z., Dai, W., Chen, R., Fu, S., Huang, H., Chi, H., Cai, Y., Deng, Z., Liu, T.* Nature Catalysis 2022 The functional coupling between restriction and DNA phosphorothioate modification systems underlying the DndFGH restriction complex Dan Wu# Yaqian Tang, Siwei Chen, Yue He,Xiaofei Chang, Wenzhong Zheng,Zixin Deng,Zhiqiang Li',Lianrong Wang*,Geng Wu &amp;Shi Chen* Nature Catalysis 2022 Systematic strategies for developing phage resistant Escherichia coli strains Xuan Zou # , Xiaohong Xiao, Ziran Mo, Yashi Ge , Xing Jiang &nbsp;, Ruolin Huang, Mengxue Li , Zixin Deng,Shi Chen* , Lianrong Wang*&amp; Sang Yup Lee* Nature Communications 2022 Nicking mechanism underlying the DNA phosphorothioate-sensing antiphage defense by SspE Haiyan Gao#, Xinqi Gong#, Jinchuan Zhou, Yubing Zhang, Jinsong Duan &nbsp;, Yue Wei &nbsp;, Liuqing Chen &nbsp;, Zixin Deng, Jiawei Wang,Shi Chen*, Geng Wu, Lianrong Wang* Nature Communications 2022 Insights into azalomycin F assembly-line contribute to evolution-guided polyketide synthase engineering and identification of intermodular recognition Guifa Zhai, Yan Zhu, Guo Sun, Fan Zhou, Yangning Sun, Zhou Hong, Chuan Dong, Peter F. Leadlay, Kui Hong, Zixin Deng, Fuling Zhou, Yuhui Sun Nature Communications 2022 Efficient oral insulin delivery enabled by transferrin-coated acid-resistant metal-organic framework nanoparticles Jun-Jie Zou, Gaohui Wei, Chuxiao Xiong, Yunhao Yu, Sihui Li, Liefeng Hu, Shengqian Ma*, Jian Tian* Science Advances 2022

  来源：武汉大学药学院

  时间：2025-03-22

• 近3年授权专利

  </colgroup> 专利名称 全部发明人 授权号 授权日期 含硒氰侧链的氧桥双环-[2.2.1]-庚烯类化合物及其制备方法与应用 周海兵,董春娥,黄健,邓湘萍,宁文涛,邓小飞 202211503440X 2024/06/28 一种基于疏水标签的酰基硫脲类化合物及其制备方法与抗甲型流感病毒的应用 周海兵,吴叔文,邹问汀 2022114591463 2024/04/26 NIR无重原子光敏剂及其制备方法和应用 丁陶陶,柳秀敏,洪学传,肖玉玲,刘奕伸,张志云,潘延娜 2022111201193 2024/01/09 双重靶向降解雌激素受体α和芳构化酶的PROTACs化合物及其应用 周海兵,董春娥,辛丽兰,程艳 2022111896012 2024/03/19 嵌合三萜合酶和三萜化合物 刘天罡 2022103785821 2024/06/11 一种用于口服蛋白质给药的金属有机框架纳米粒子及其制备方法 田间,邹俊捷 2022101127502 2024/08/23 一种以草酰氯和格氏试剂为原料合成α-酮酸的方法 贾涛,胡月 2022100079925 2024/01/30 具有聚集诱导发光性质的近红外二区荧光化合物及其制备方法和应用 肖玉玲,李扬,洪学传,崔岩 2021107488162 2024/02/02 维生素E的制备新方法 刘天罡,沈坤,邓子新 2021104659906 2024/02/27 代谢改造提升异源多杀菌素菌株发酵产量的方法 刘天罡,刘然 2021100144690 2024/07/12 一种瑞德西韦或其中间体的PROTAC化合物及其制备方法与抗EV71的应用 周海兵,吴叔文,麻笑雨 2022115206196 2024/11/22 氧桥双环-[2.2.1]-庚烯类化合物在制备抗新型冠状病毒药物中的应用 周海兵,吴叔文,蓝柯,辛丽兰,张寒秋 2022115329961 2024/11/15 Hangtaimycin衍生物及其制备方法和应用 孙宇辉,李艳琴,项瑾,罗明和,邓子新 2022106390693 2024/11/5 一种萜类合酶基因及其表达盒、表达载体和重组微生物菌株 刘天罡 2021113061304 2024/11/15 一种含有五元氮杂环的氧桥双环庚烯磺酰胺类化合物及其在制备抗乳腺癌药物中的应用 周海兵,董春娥,辛丽兰,李媛媛 2022101342138 2023/2/24 一种含疏水标签的氧桥双环庚烯磺酰胺类化合物及其应用 周海兵,董春娥,辛丽兰,胡志烨 2021110766981 2023/4/7 一种含有五元氮杂环的氧桥双环庚烯磺酸酯类化合物及其在制备抗乳腺癌药物中的应用 周海兵,董春娥,辛丽兰,李媛媛 2022101347790 2023/6/6 一种含有不同共价弹头结构的氧桥双环-[2.2.1]-庚烯类化合物及其制备与应用 董春娥,周海兵,王禹博,冯甜,程艳 2021109540325 2023/6/30 一种酰胺类化合物、其应用及抗肿瘤药物组合物 余建清,韦玉璐,万倩,刘清钰,徐婕,刘星星 2022107788528 2023/8/15 一种托品酮的合成方法 瞿旭东,林芝 2021115499050 2023/8/18 单胺氧化酶在制备托品酮中的应用 瞿旭东,林芝 2021115499366 2023/11/7 闭式胸腔引流装置 熊娟; 胡晓晴; 郑瑶; 李银霜 2022221212081 2023/5/9 一种2, 5芳基取代对二酚的合成方法 王巍 2022106919993 2023/6/27 红景天苷水凝胶制剂及其制备方法和应用 洪学传; 蔡杰; 何胜楠; 谢芳 2021112712524 2023/12/8 通过优化碳源提升异源多杀菌素表达菌株发酵产量的方法 刘天罡; 刘然 2021100132157 2023/12/8 可在体内长时间循环的有机荧光小分子化合物及其制备方法和应用 肖玉玲,李扬,洪学传 2021101155372 2023/6/27 一类化合物、其合成基因簇及应用 洪葵；郭晶晶；邓子新 2020114747608 2022/1/4 以氧桥双环庚烯类化合物为雌激素受体配体的蛋白水解靶向嵌合体化合物及制备方法与应用 周海兵；胡志烨；宁文涛；黄健；董春娥 2020105817777 2022/2/15 伊马替尼及其衍生物与成瘾物质联合用药或复方制剂在预防、治疗成瘾及防治复吸中的应用 李艳琴；朱世敏；张新宇；陈明珠 2019109391003 2022/4/1 c-Kit作为行为成瘾治疗靶点的应用 李艳琴；朱世敏；陈明珠；张新宇 2019109396882 2022/4/1 基于金属有机骨架的β-葡萄糖醛酸苷酶探针及应用 肖玉秀；李朔 2021108505150 2022/6/7 一种酰基硫脲类化合物在制备抗肠道病毒药物中的应用 周海兵；吴叔文；许智超；刘欣瑾 2021109066292 2022/6/14 基于双发射镧系MOF的碱性磷酸酶检测试剂盒及检测方法 肖玉秀；于龙 2021100177285 2022/7/5 倍半萜类化合物及其制备方法和在制备抗肿瘤药物中的应用 余建清；郑小琴；吴姿；徐婕 2021101253835 2022/7/5 一种植物细胞分裂素狭霉素的生物合成基因簇及其生物材料以及在合成狭霉素中的应用 陈文青；于乐；邓子新；周文婷；佘一玄 2021106894027 2022/7/5 一种基于烷醇低共熔溶剂的萃取-反萃取体系及其应用 肖玉秀；黄安琪 2021107907471 2022/7/19 化学合成的具有抗细菌、真菌作用的二聚体多肽、制备方法及其应用 沈秉正；周本宏；刘刚；吴玥 2020109224200 2022/8/9 一种基于丙烯酰胺导电凝胶的无鞘流CE-MS接口装置及应用 陈子林；周韦；孙文琦 2020116081555 2022/8/30 一种抗噬菌体和抗病毒系统 王连荣；陈实；王诗维；邓子新 2021103898295 2022/9/13 一株高产多杀菌素的刺糖多孢菌 刘天罡；刘然；邓子新 2021106704198 2022/10/4 c-Kit作为成瘾诊断及监测标志物的应用 李艳琴；洪学传；陈子林；朱世敏；张新宇；陈明珠 2019109396774 2022/10/4 一种嵌合萜类合酶及其应用 刘天罡；陈蓉；卞光凯；叶紫玲；慕昕 2021106184564 2022/11/18 伊马替尼及其衍生物与尼古丁或其类似物联用或复方在防治尼古丁成瘾与复吸中的应用 李艳琴；朱世敏；张新宇；陈明珠 2019109391130 2022/12/2 一种环糊精微孔有机网材料及其制备方法和应用 陈子林,李振涛 2021104139329 2022/2/1 糖基聚醚化合物在制备抗副粘病毒或肠道病毒药物的用途 刘天罡; 黄敏坚; 陈明周; 李智菲 202110208092.2 2022/12/27 一种个性化癌症用药数据库系统及建立方法 项瑾; 戚苗苗; 王昕 201911128713.5 2022/7/12 靶向乳腺癌的多功能纳米颗粒、其制备方法及其应用 项瑾; 王昕; 戚苗苗; 王淏宇 202110763992.3 2022/11/22

  来源：武汉大学药学院

  时间：2025-03-22

• 综述：照亮口腔健康：用于光诊疗的聚集诱导发光材料

  本文综述了聚集诱导发光材料（AIEgens）在口腔疾病光诊疗中的应用及进展，前景广阔但仍面临挑战。

  来源：Cell Biomaterials

  时间：2025-03-21

• 基于近红外二区光声偏振增强光学旋转传感的深组织手性分子检测新方法

  本研究针对传统手性分子检测技术在深组织检测中的局限性，提出了一种基于近红外二区（NIR-II）光声偏振增强光学旋转传感（PAPEORS）的新方法，实现了深至3.5 mm组织的手性分子浓度检测，为体内手性分子传感提供了新思路。

  来源：SCIENCE ADVANCES 11.7

  时间：2025-03-20

• 光动力凝胶炸弹：突破肿瘤治疗困境的新利器

  为解决纳米颗粒药物递送系统穿透难题，研究人员研发光动力凝胶炸弹（DCM@OPR），显著增强乳腺癌治疗效果。

  来源：Signal Transduction and Targeted Therapy

  时间：2025-03-20

• 综述：光声成像在再生医学中的应用洞察

  光声成像（PAI）在再生医学等领域应用广泛，前景广阔但面临挑战。

  来源：Discover Imaging

  时间：2025-03-15

• 基于白蛋白的近红外二区荧光蛋白：血睾屏障完整性无创成像的新突破

  本文利用近红外二区（NIR-II）染料，通过优化白蛋白结合及定点突变技术，实现血睾屏障（BTB）完整性的无创成像。

  来源：Cell Reports Physical Science 7.9

  时间：2025-03-14

• 具有聚集诱导发光和聚集猝灭特性的可激活第二近红外窗口多模态发光团用于肿瘤治疗的分步成像引导

  为解决传统有机发光团在复杂环境应用受限问题，研究人员构建 DPM-HD_1-3及 DPM-HD₃-CO，实现肿瘤精准治疗。

  来源：Nature Communications 14.7

  时间：2025-03-13

• 新型软骨靶向荧光团 CARF28：类风湿关节炎诊疗的新希望

  为解决类风湿关节炎（RA）早期诊断难题，研究人员开发 CARF28，可精准成像，助力诊疗。

  来源：Chem 19.1

  时间：2025-03-13

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