《中国神经再生研究（英文版）》杂志内容综览

　　

腺病毒介导葡萄糖转运体3抑制缺血损伤PC12细胞的凋亡
  
  
《中国神经再生研究（英文版）》杂志于2012年6月17期出版的一项关于“Adenovirus-mediated transfection with glucose transporter 3 suppresses PC12 cell apoptosis following ischemic injury”的研究显示，①转染腺病毒介导的葡萄糖转运体3能明显抑制缺血损伤诱导的大鼠PC12细胞的凋亡。②转染腺病毒介导的葡萄糖转运体3可提高缺血损伤大鼠PC12细胞葡萄糖摄取率。③转染腺病毒介导的葡萄糖转运体3可下调缺血损伤大鼠PC12细胞核因子κB的表达。作者认为，腺病毒介导的葡萄糖转运体3转染可改善缺血损伤PC12细胞的能量代谢，降低核因子κB的表达，抑制细胞凋亡。

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Article: " Adenovirus-mediated transfection with glucose transporter 3 suppresses PC12 cell apoptosis following ischemic injury " by Junliang Li1, Xinke Xu1, Shanyi Zhang1, Meiguang Zheng1, Zhonghua Wu2, Yinlun Weng1, Leping Ouyang1, Jian Yu1, Fangcheng Li1 (1Department of Neurosurgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, Guangdong Province, China; 2Department of Neurosurgery, Henan Provincial People’s Hospital, Zhengzhou 450003, Henan Province, China)

 

串珠素和突触素在骨骼肌失神经支配后的反应
 
 
《中国神经再生研究（英文版）》杂志于2012年6月17期出版的一项关于“Perlecan and synaptophysin changes in denervated skeletal muscle”的研究显示，①坐骨神经切断后局部立刻发生溃变，并形成炎性改变；与此相对应的是其所支配的骨骼肌发生变性改变，而炎症表现不明显。②随着坐骨神经损伤时间的延长，骨骼肌串珠素的表达逐渐下降。③突触素的表达在大鼠骨骼肌失神经支配后变化不明显。作者认为，骨骼肌萎缩主要是源于失神经支配而造成的营养障碍；串珠素的表达水平对于骨骼肌失神经后的反应比突触素更敏感，能反映骨骼肌失神经后局部细胞外基质的变化。

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Article: " Perlecan and synaptophysin changes in denervated skeletal muscle " by Kai Ma1, 2, Zhifeng Huang3, Jianfeng Ma2, Longquan Shao4, Huiming Wang1, Yanliang Wang2 (1 Department of Oral and Maxillofacial Surgery, Affiliated Hospital of Stomatology, Medical College of Zhejiang University, Hangzhou 310006, Zhejiang Province, China; 2 Department of Oral and Maxillofacial Surgery, Affiliated Hospital of Stomatology, Wenzhou Medical College, Wenzhou 325027, Zhejiang Province, China; 3 School of Pharmacy, Wenzhou Medical College, Wenzhou 325000, Zhejiang Province, China; 4 Department of Stomatology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong Province, China)

脉冲磁刺激提高大鼠损伤坐骨神经的可塑性
    
  
经脊髓磁刺激已被证实对脊髓和脑、周围神经的神经可塑性有促进作用。《中国神经再生研究（英文版）》杂志于2012年6月17期出版的一项关于“IMS facilitates synaptic regeneration following sciatic nerve injury”的研究显示，坐骨神经钳夹伤大鼠经脊髓和脊神经根高频脉冲磁刺激1个月后，电镜下观察到损伤节段及以下水平神经组织炎症和脱髓鞘程度减轻、凋亡细胞减少，损伤的许旺细胞和有髓神经纤维得到修复。作者认为，经脊髓和对应的脊神经根高频脉冲磁刺激对坐骨神经损伤后神经再生有促进作用。

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Article: " Impulse magnetic stimulation facilitates synaptic regeneration in rats following sciatic nerve injury," by Sergey A. Zhivolupov, Miroslav M. Odinak, Nariman A. Rashidov, Ludmila S. Onischenko, Igor N. Samartsev, Anton A. Jurin (Department of Neurology, Military-Medical Academy, Saint-Petersburg, 194044, Lesnoy prospect 2, Russian Federation)

 

补阳还五汤诱导骨髓间充质干细胞分化的丝裂原活化蛋白激酶信号通路  
  
 
《中国神经再生研究（英文版）》杂志于2012年6月18期出版的一项关于“MAPK pathways participate in the active principle region of Buyang Huanwu decoction-induced differentiation of bone marrow mesenchymal stem cells”的研究显示，丝裂原活化蛋白激酶信号通路中的细胞外调节蛋白激酶和丝裂原活化蛋白激酶信号通路p38蛋白均参与补阳还五汤有效部位方诱导的骨髓间充质干细胞的分化。证实补阳还五汤有效部位方可以在体外诱导骨髓间充质干细胞向神经细胞方向分化，并描述了丝裂原活化蛋白激酶通路在其中所发挥的作用。

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Article: " Mitogen activated protein kinase signaling pathways participate in the active principle region of Buyang Huanwu decoction-induced differentiation of bone marrow mesenchymal stem cells," by Jinghui Zheng, Jian Liang, Xin Deng, Xiaofeng Chen, Fasheng Wu, Xiaofang Zhao, Yuan Luo, Lei Fu, Zuling Jiang(Ruikang Hospital Attached to Guangxi Traditional Chinese Medicine College, Level-3 Laboratory of Cell Molecular Biology of State Administration of Traditional Chinese Medicine of the People’s Republic of China, Nanning 530011, Guangxi Zhuang Autonomous Region, China)