《自然》重点评述中国科学家文章

　　

生物通报道：英国著名杂志《Nature》是世界上最早的国际性科技期刊之一，自从1869年创刊以来，始终如一地报道和评论着全球科技领域里最重要的突破，是研究人员了解和掌握本领域研究动态的一种重要手段。

近期《Nature》网站推出了《Nature China》子刊栏目，主要目的就是将中国大陆以及香港地区的优秀研究成果介绍给全球的科学家们，并提供一个更好更方便的了解窗口。目前这一网站（http://www.nature.com/nchina/index.html）以beta form的形式提供了自2000年起的《Nature》杂志，以及其它顶级科学刊物中出版的中国科学家的一些优秀研究成果的简短评述摘要，另外对于《Nature》杂志，这里也提供了全文的查询途径。

目前这一网站每隔一个星期就会挑选近期出版的优秀研究成果，以摘要的形式刊登出来，读者可以推荐一些文章进行投票，其中最好的将会被选入《Nature China》。

近期研究热点生物类：

[Cell & molecular biology]
SARS virus: A channel for escape 
Dangsheng Li

Published online: 28 February 2007 | doi:10.1038/nchina.2007.12

Original article citation:
Lu, W. et al. Severe acute respiratory syndrome-associated coronavirus 3a protein forms an ion channel and modulates virus release. Natl Acad. Sci. 103, 12540–12545 (2006).


Tight junctions: How to stick cells together 
Dangsheng Li

Published online: 28 February 2007 | doi:10.1038/nchina.2007.13

Original article citation:
Wang, Y. et al. Tyrosine phosphorylated Par3 regulates epithelial tight junction assembly promoted by EGFR signaling. EMBO J. 25, 5058–5070 (2006).

 
[Clinical medicine]
Cancer: A suppressor suppressed 
Jim Casey

Published online: 28 February 2007 | doi:10.1038/nchina.2007.15

Original article citation:
Lo, K.-W. et al. High Frequency of Promoter Hypermethylation of RASSF1A in Nasopharyngeal Carcinoma. Cancer Res. 61, 3877–3881 (2001).


SARS: Bat reservoir for virus? 
Jim Casey

Published online: 28 February 2007 | doi:10.1038/nchina.2007.16

Original article citation:
Lau, S. K. P. et al. Severe acute respiratory syndrome coronavirus-like virus in Chinese horseshoe bats. Proc. Natl Acad. Sci.USA 102, 14040–14045 (2005).


Bird flu: A cytokine storm? 
Jim Casey

Published online: 28 February 2007 | doi:10.1038/nchina.2007.17

Original article citation:
Chan, M. C. W. et al. Proinflammatory cytokine responses induced by influenza A (H5N1) viruses in primary human alveolar and bronchial epithelial cells. Respir. Res. 6, 135 (2005).

 
SARS: Host unknown 
Jim Casey

Published online: 28 February 2007 | doi:10.1038/nchina.2007.18

Original article citation:
Song, H.-D. Cross-host evolution of severe acute respiratory syndrome coronavirus in palm civet and human. Proc. Natl Acad. Sci. USA 102, 2430–2435 (2005).


Heart failure: Pacemaking it better 
John Fox

Published online: 28 February 2007 | doi:10.1038/nchina.2007.19

Original article citation:
Yu, C.-M. et al. Tissue Doppler echocardiographic evidence of reverse remodeling and improved synchronicity by simultaneously delaying regional contraction after biventricular pacing therapy in heart failure. Circulation 105, 438–445 (2002).


Heart failure: Doppler imaging best 
John Fox

Published online: 28 February 2007 | doi:10.1038/nchina.2007.20

Original article citation:
Yu, C.-M. et al. Tissue Doppler imaging is superior to strain rate imaging and postsystolic shortening on the prediction of reverse remodeling in both ischemic and nonischemic heart failure after cardiac resynchronization therapy. Circulation 110, 66–73 (2004).


Pneumonia: A new coronavirus 
John Fox

Published online: 28 February 2007 | doi:10.1038/nchina.2007.21

Original article citation:
Woo, P. C. Y. et al. Characterization and complete genome sequence of a novel coronavirus, coronavirus HKU1, from patients with pneumonia. J. Virol. 79, 884–895 (2006).

　

[Developmental biology]
Worm development: Cutting shapes 
Dangsheng Li

Published online: 28 February 2007 | doi:10.1038/nchina.2007.14

Original article citation:
Yu, R. Y. L. , Nguyen, C. Q. , Hall, D. H. & Chow, K. L. Expression of ram-5 in the structural cell is required for sensory ray morphogenesis in Caenorhabditis elegans male tail. EMBO J. 19, 3542–3555 (2000).

 
[Neuroscience]
Alzheimer's: A stressful development 
Dangsheng Li

Published online: 28 February 2007 | doi:10.1038/nchina.2007.11

Original article citation:
Ni Y. et al. Activation of 2-adrenergic receptor stimulates -secretase activity and accelerates amyloid plaque formation. Nature Med. 12, 1390–1396 (2006).

（生物通：张迪）