本期自然杂志：华人科学家与韩国科学家同领域研究成果

　　

生物通综合： 本期的Nature杂志有两项研究成果与帕金森症研究相关：

Nature 441, 1162-1166 (29 June 2006)
Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin
[Abstract]

Nature 441, 1157-1161 (29 June 2006)
Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin
[Abstract]

第一篇来自美加州大学David Geffen医学院的Ming Guo研究小组，第二篇来自韩国细胞生长调控创新研究所（National Creative Research Initiatives Center for Cell Growth Regulation），这两个研究小组对果蝇中相应的基因进行了研究，发现它在活体中局限于线粒体中，对线粒体的功能非常重要。它还在遗传上与parkin基因发生相互作用，后者是与家族性帕金森氏症有关的另一个基因，为一种E3泛素连接酶编码。果蝇的pink1-parkin通道应能为研究神经退化的分子机制、为可能的治疗方案筛选药物提供一个强大的工具。

附：Ming Guo

Graduate：
M.D., 1989, Shanghai Medical University 
Ph.D., 1996, University of California, San Francisco, Thesis Adviser: Dr. Yuh Nung Jan in Howard Hughes Medical Institute

Honors：

2003 2003 2003 2002 2002 2001 2001 2001 2000 1993 1991 1989 1989

The Ellison Medical Foundation New Scholar Award in Aging The Larry L. Hillblom Foundation Startup Grantee Board Certification in Neurology, American Board of Psychiatry & Neurology National Institute of Health, Clinical Scientist Career Development Award Art Linkletter Award, the John Douglas French Alzheimer's Foundation The John Douglas French Alzheimer’s Foundation Fellowship The Giannini Medical Foundation Fellowship Jean-Louis Riehl Award for Outstanding Research during Neurology Residency Resident Research Award, Neurology, UCLA Nonresident Tuition Scholarship, UCSF Nonresident Tuition Scholarship, UCSF Regents Fellowship, University of California International Fellowship, American Association of University Women (AAUW)

（生物通：万纹）