戴宏杰研究小组文章：癌症治疗新研究

　　

生物通报道：来自美国斯坦福大学化学系的戴宏杰（Hongjie Dai，音译）研究小组成员将核磁共振技术和红外辐射技术相结合，制成了一种集成这两种功能的纳米微型系统，可以用于局部加热，激发一种治疗效果，这为癌症治疗提供了新的材料和手段。这一研究成果公布在12月的《Nature-Nanotechnology》杂志上。

原文摘要：
Nature Nanotechnology Published online: 17 December 2006 | 
doi:10.1038/nnano.2006.170
In vivo biodistribution and highly efficient tumour targeting of carbon nanotubes in mice
[Abstract]

核磁共振仪可用于血管成像，而附近的红外辐射则可用来消灭恶性细胞，在这篇文章中，研究人员设计了集成这两种功能的纳米微型系统，这个系统还有两个优点：可溶于水和无毒。这个纳米系统由铁-钴合金外包一层石墨碳构成。铁-钴核心具有超强磁性，因此与常用的钆造影剂相比，更低剂量的铁-钴纳米颗粒可得到更高清晰度的磁共振成像。石墨碳外壳还有另外一层意义，它能保护铁-钴核心更稳定更强壮。这个纳米颗粒的表面也功能化为可溶于充满水的身体，延长了成像的时间。而且，这个颗粒能吸收邻近的红外光。作者表示这种现象可用于局部加热，激发一种治疗效果，比如杀死癌细胞。
（生物通：万纹）

附：
美国斯坦福大学化学系：Hongjie Dai的研究小组 

【URL】 http://www.stanford.edu/dept/chemistry/faculty/dai/group/

【简介】
The research of Dai group interfaces with chemistry, physics, materials science and biophysics. They are interested in solid state and soft condensed materials that have well-defined atomic structures. Ongoing projects include developing new synthetic routes to ordered nanomaterial architectures; electrical, mechanical, electromechanical and electrochemical characterizations at the nanoscale; and probing the real-space structures and functions of biological molecules. Their work are in the areas of material chemistry, inorganic synthesis, solid state physics, electron transport and scanning probe microscopy. A specific research program involves the development of new synthesis methods to obtain ordered carbon nanotube architectures on surfaces. These novel nanowire architectures are ideal model systems for addressing fundamental physics problems in low dimensions, and for future device applications. Their overall approach involves the combination of inorganic synthesis of mesoporous catalytic materials and chemical vapor deposition with microfabrication techniques. With the synthesized nanowire architectures, they are carrying out electrical and electromechanical measurements of individual nanotube molecular wires, aimed to understand the properties of quasi-one-dimensional solids, elucidating quantum mechanical effects in small systems, and explore their applications in future miniaturized devices. 

Another project involves using scanning probe microscopy techniques to probe the structural properties of biological macromolecules, and elucidate the interactions between individual molecular pairs. 
Camille and Henry Dreyfus New Faculty Award, 1997; Terman Fellowship, 1998; Packard Fellowship for Science and Engineering, 1999; Alfred P. Sloan Research Fellow, 2001; American Chemical Society Pure Chemistry Award, 2002; Camille Dreyfus Teacher-Scholar Award, 2002 

Department of Chemistry 
Stanford University 
Stanford, CA 94305-5080 USA 

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