蒋如朗教授学术简介

　　

近期的Science发表了一篇有趣的文章（文章标题：Antagonistic Actions of Msx1 and Osr2 Pattern Mammalian Teeth into a Single Row），这篇原创性文章很新颖，有位教授带领的研究小组破解了人的牙床只长一排牙齿的秘密。这位教授就是蒋如朗教授。

相关专访文章：http://www.ebiotrade.com/newsf/2009-3/2009313171519.htm

Rulang Jiang, Ph.D.
Associate Professor (with tenure)

Center for Oral Biology and
Department of Biomedical Genetics  Telephone: [phone] (office)
University of Rochester      585-273-1422 (lab)
School of Medicine and Dentistry   Fax:  [phone]
601 Elmwood Avenue, Box 611  email: [e-mail]
Rochester, New York 14642, USA

EDUCATION

1984 B. S., Biology, Nanjing Normal University, Nanjing, China
1987 M. S., Genetics, Chinese Academy of Sciences, Beijing, China
1995 Ph.D., Biology, Wesleyan University, Middletown, CT, USA

HONORS AND AWARDS

1991  Arthur Klorfein Fund Scholarship
1994  Sigma Xi Student Research Award
1994-1995 Roche Postdoctoral Fellowship
1997-1998 NIH Individual NRSA Postdoctoral Fellowship
2000-2002 Basil O’Connor Starter Scholar, March of Dimes Birth Defect Foundation

RESEARCH AND/OR PROFESSIONAL EXPERIENCE

1984 – 1987 M. S. Thesis Research, Institute of Genetics, Chinese Academy of Sciences, Beijing, China
1987 – 1988 Research Scientist, Institute of Genetics, Chinese Academy of Sciences, Beijing, China
1989 – 1994 Ph.D. candidate, Biology Department, Wesleyan University
1994 – 1995 Postdoctoral Associate, Roche Institute of Molecular Biology, Nutley, New Jersey
1995 – 1998 NIH Postdoctoral Fellow, The Jackson Laboratory, Bar Harbor, Maine
1999 – 2004 Assistant Professor, Center for Oral Biology, University of Rochester
1999 – 2004 Assistant Professor, Department of Biology, University of Rochester
2002 – 2004 Assistant Professor, Department of Biomedical Genetics, University of Rochester
2004 – present Associate Professor (with tenure), Center for Oral Biology and Department of Biomedical Genetics, University of Rochester School of Medicine and Dentistry
2004 – present Associate Professor, Eastman Department of Dentistry, University of Rochester School of Medicine and Dentistry

MEMBERSHIP IN PROFESSIONAL SOCIETIES

Society for Developmental Biology, 2002 - present
International/American Association for Dental Research, 2003 – present
Society of Craniofacial Genetics, 2004 - present

TEACHING EXPERIENCE
1999 BIO228L, Laboratory of Cell and Developmental Biology
 BIO407/GEN507, Advanced Genetics
 BIO516, Current Topics in Developmental Genetics (Course Director)
2000 BIO228L, Laboratory of Cell and Developmental Biology
2001 BIO437, Advanced Developmental Biology (Course Director)
2002 ORB558, Craniofacial Growth and Development
2003 GEN508, Genes, Development and Disease (Course Director)
2003 GEN507, Advanced Genetics (Mouse Genetics section)
2004 GEN508, Genes, Development and Disease (Course Director)
2004 GEN507, Advanced Genetics (Mouse Genetics section)
2005 GEN508, Genes, Development and Disease (Course Director)
2005 GEN507, Advanced Genetics (Mouse Genetics section)
2005 ORB558, Craniofacial Growth and Development
2006 GEN508, Genes, Development and Disease (Course Director)
2006 GEN507, Advanced Genetics (Mouse Genetics section)
2007 ORB558, Craniofacial Growth and Development
2008 GEN508, Genomics and Systems Biology (Course Director)
2009 GEN508, Genomics and Systems Biology (Course Director)

GRADUATE STUDENT MENTORING
Advisor to Jeffrey Bush, Ph.D. in Biology  (2000 – 2004)
Advisor to Pearl Griffin, M.S. Graduate student of Biology  (2001 – 2002)
Advisor to Han Liu, Ph.D candidate in Biology (2003 - present)
Advisor to Jianquan Chen, Ph.D candidate in Biology (2005 – present)
Advisor to Wenjin Liu, Ph.D candidate in Biochemistry (2005 – present)
Advisor to Rosemary Ryan, M.S. in Biology (2005 – 2006)
Advisor to Yang Gao, Ph.D candidate in GGD (2006 – present)
Advisor to Yuan Zhang, Ph.D candidate in GGD (2007-present)
Member of thesis advisory committees for over 20 graduate students in the last five years in several graduate degree programs, including Biology, Biochemistry, Genetics, Neuroscience, Oral Biology, and Pathology.
 
POSTODOCTORAL EDUCATION
Eui-Sic Cho, DDS, Ph.D., 2000 – 2002.  (Current position: Professor, Chonbuk National University, Korea.)
Liam Casey, Ph.D., 2003 – 2006.  Current position: Instructor – URMC.
Jeffrey Bush, Ph.D., 2004 – 2005  Current position: Postdoc at Mt. Sinai.
Zunyi Zhang, Ph.D., 2005 – 2006. (Current position: Research Assistant Professor, University of Rochester)
Shihai Jia, Ph.D., 2008 – present.
Jin-A Baek, DDS, Ph.D., 2008 – present.

UNDERGRADUATE THESIS RESEARCH
Ensel Oh, Department of Biology, 2001
Deepak Sobti, Department of Biology, 2003

SUMMER DENTAL STUDENT RESEARCH TRAINING
Cathy Wiltshire, summer minority dental student, 2002
Karan Estwick, summer minority dental student, 2003
Lisa DeLucia, Summer minority dental student, 2004
Pamela Torres, Summer minority dental student, 2005

INTRAMURAL PROFESSIONAL AND ADMINISTRATIVE ACTIVITIES
Member, Dean’s Research Advisory Committee, School of Medicine and Dentistry (2001 - 2008)
Co-Chair, Dentistry Research Oversight Committee (2004 – 2007)
Departmental Representative, Medical Faculty Council, URMC (2001 - 2005)
Member, UR Transgenic Mouse Facility Oversight Committee (2000 – present)
Member, Graduate Admissions Committee, Department of Biology  (1999 - 2005)
Member, Graduate Admissions Committee, BMCB cluster (2002 - 2003)
Member, Graduate Admissions Committee, GDD cluster (2003 - present)
Chair, Developmental Biology Faculty Search Committee, Center for Oral Biology (2002, 2004, 2006)
Organizer, Center for Oral Biology Seminar (Bagel Talk) Series (2003 – present)
Secretary/Treasurer, American Association of Dental Research, Rochester section (2005-2006)
Chair, Rochester AADR annual meeting (2005, 2006)
President, AADR Rochester Section (2006–2008)
Member, Mouse User Group/Vivarium Oversight Committee, 2008 - present

EXTRAMURAL PROFESSIONAL ACTIVITIES
Editorial Board, Journal of Dental Research, 2003 – 2005
 Secretary/Treasurer, AADR Rochester Section, 2004 – 2006
 President, AADR Rochester Section, 2006 - 2008
 Ad hoc reviewer, Development, Developmental Biology, BMC Developmental Biology, PLoS Genetics, Developmental Dynamics, Mechanisms of Development, Gene Expression Patterns, Stem Cell, Birth Defects Research, Biochemical Journal, Nucleic Acid Research, Journal of Dental Research, Journal of Biological Chemistry, Journal of Bone and Mineral Research, Oral Disease, Molecular Medicine, Lancet.
 Ad hoc reviewer, NIH SBDD study section, 2004, 2005, 2006
Ad hoc reviewer, NIH NICHD Special Emphasis Panel on Comparative Genetics of Structural Birth Defects, 2004
 Ad hoc reviewer, NIH CHHD-C study section, 2004
 Ad hoc reviewer, NIDCR Special Emphasis Panel, 2006
 Grant reviewer, National Natural Science Foundation of China, 2004 – present
 Ad hoc grant reviewer, The Wellcome Trust, UK. 2003 – present
 Member, College of Reviewers, Canada Research Chairs Program, 2005-2006
 Ad hoc reviewer, NICHD Special Emphasis Panel ZHD1, 2009

GRANTS AND CONTRACTS
Active:
1. NIH R01 DE013681  “Molecular Genetic Analysis of Craniofacial Development”
 Principal Investigator:  Rulang Jiang
 Award Amount: $1,815,905.
 04/01/2005 – 02/28/2010 (Years 6 – 10)
 
2. NIH R01 DE015207  “Genetic Basis of Cleft Lip and Palate”
 Principal Investigator:  Rulang Jiang
 Award Amount: $1,840,300.
 04/01/2008 – 01/31/2013 (Years 5 – 9)

3. NIH P50 DE16215 “Craniofacial Anomalies Research Center”
Program Director: Jeffrey Murray (University of Iowa)
Project 5 “ Oral Cleft Pathogenesis in a Mutant Mouse Model”
Project 5 Principal Investigator: Rulang Jiang
Award Amount (Project 5): 1,140,184.
09/20/2004 – 07/31/2009

Pending:
1. NIH R01 DE18401-01 “Molecular Patterning of Mammalian Dentition”
 Principal Investigator: Rulang Jiang
 Amount Requested: $1,950,000
 (This new R01 grant application received a priority score of 20.5% by the SBDD study section in March 2008. A revised version will be submitted in early 2009.)

2.  NIH U01DE020059 “Palate Molecular Atlas Research Project”
 Principal Investigators: Rulang Jiang (Contact PI) Yang Chai, YiPing Chen
 Amount Requested: $2,532,864
 09/01/09 – 08/31/14
 (This is a new application submitted in January 2009 in response to NIDCR FaceBase U01 RFA.)
 
Completed:
1. NIH F32 HD08214 “Mesoderm and Neural Crest Development”
Principal Investigator: Rulang Jiang (Postdoctoral fellowship)
01/01/97 – 12/18/98,

2. ACS IRG-98-276-02 “Notch Signaling in Mammalian Development”
 Principal Investigator: Rulang Jiang
 Award Amount: $8,000
 08/01/99 – 07/31/00,

3. MOD 5-FY99-788  “Notch Signaling in Craniofacial and Neural Development”
 Principal Investigator: Rulang Jiang
 Award Amount: $100,000
 02/01/00 – 01/31/02,

4. NIH R03 DC04375  “Hair Cell Development in the Inner Ear”
 Principal Investigator: Rulang Jiang
 Award Amount: $162,180
 01/01/00 – 12/31/02.

5.  NIH R01 DE13681  “Molecular Genetic Analysis of Craniofacial Development”
 Principal Investigator:  Rulang Jiang
 Award Amount: $1,351,500.
 04/01/00 – 03/31/05  (This grant was successfully renewed and is currently funded through 02/28/2010.)

6. NIH R21 DE14593  “Molecular Pathogenesis of Orofacial Clefting”
 Principal Investigator:  Rulang Jiang
 Award Amount: $226,800.
 06/01/03 – 05/31/06

7. NIH R01 DE15207  “Genetic Basis of Cleft Lip and Palate”
 Principal Investigator:  Rulang Jiang
 Award Amount: $1,575,000.
 04/01/03 – 03/31/08 (This grant was successfully renewed and is currently funded through 01/31/2013.)

PUBLICATIONS

1. Jiang, R., and Liang, H. (1989).  Biological effects of high- and low-energy laser irradiation. In:  Application of Lasers in Biology and Medicine (ed. J. Li and H. Liang), pp. 35-41.  Science Press, Beijing.
2. Jiang, R., and Liang, H. (1989).  Mitotic reversion in prophase of PTK1 cells induced by argon laser microirradiation.  Cell Biophysics 14:271-282.
3. Jiang, R., Lu, Z., and Liang, H.  (1989).  Use of laser microbeam irradiation as a tool in the characterization of chromosome structure and function.  In:  Application of Lasers in Biology and Medicine (ed. J. Li and H. Liang), pp. 189-210.  Science Press, Beijing.
4.   Jiang, R., and Liang, H.  (1991).  A comparative study of cell killing effects of HPD plus laser irradiation on HeLa cells of different cell cycle stages.  Chinese Journal of Lasers 18:316-320.
5.   Jiang, R., and Grabel, L.B. (1995).  Function and differential expression of 6 integrin isoforms during parietal endoderm differentiation.  Experimental Cell Research 217:195-204.
6.   Jiang, R., Kato, M., Bernfield, M., and Grabel, L.B.  (1995).  Expression of syndecan-1 changes during the differentiation of visceral and parietal endoderm from murine F9 teratocarcinoma cells.  Differentiation 59:225-233.
7.   Jiang, R., Copeland, N.G., Gilbert, D.J., Jenkins, N.A., and Gridley, T.  (1997).  Genomic organization and chromosomal localization of the mouse Snail (Sna) gene.  Mammalian Genome 8:686-688.
8.   Jiang, R., and Gridley, T.  (1997).  Gene targeting:  Things go better with Cre.  Current Biology 7:R321-323.
9.   Lan, Y., Jiang, R., Shawber, C., Weinmaster, G., and Gridley, T.  (1997).  The Jagged2 gene maps to chromosome 12 and is a candidate for the lgl and sm mutations.  Mammalian Genome 8:875-876.
10.  Bell, S., Lan, Y., Jiang, R., and Gridley, T.  (1998).  Exclusion of Jagged2 as a candidate for the legless gene.  Mammalian Genome 9:778-779.
11.  Jiang, R., Norton, C.R., Copeland, N.G., Gilbert, D.J., Jenkins, N.A., and Gridley, T.  (1998).  Genomic organization, expression and chromosomal localization of the mouse Slug (Slugh) gene.  Biochemica et Biophysica Acta 1443:251-254.
12.  Jiang, R., Lan, Y., Chapman, H.D., Shawber, C., Norton, C.R., Serreze, D.V., Weinmaster, G., and Gridley, T.  (1998).  Defects in limb, craniofacial and thymic development in Jagged2 mutant mice.  Genes & Development 12:1046-1057.
13.  Jiang, R., Lan, Y., Norton, C.R., and Gridley, T.  (1998).  The Slug gene is not essential for mesoderm or neural crest development in mice.  Developmental Biology 198:277-285.
14.  Lanford, P.J., Lan, Y., Jiang, R., Lindsell, C., Weinmaster, G., Gridley, T., and Kelley, M.W.  (1999).  Notch signaling mediates Hair cell development in mammalian cochlea.  Nature Genetics  21:289-292.
15.  McCright, B., Gao, X., Lozier, J., Lan, Y., Shen, L., Maguire, M., Herzlinger, D., Weinmaster, G., Jiang, R., and Gridley, T. (2001).  Defects in development of the kidney, heart and eye vasculature in mice homozygous for a hypomorphic Notch2 mutation.  Development 128:491-502.
16.  Lan, Y., Kingsley, P. D., Cho, E. S., and Jiang, R. (2001).  Osr2, a new mouse gene related to Drosophila odd-skipped exhibits dynamic expression patterns during craniofacial, limb, and kidney development.  Mechanisms of Development 107:175-179.
17.  *Carver, E. A., *Jiang, R., Lan, Y., Oram, K. F., and Gridley, T. (2001).  The mouse Snail gene encodes a key regulator of the epithelial-mesenchymal transition. Molecular and Cellular Biology 21:8184-8188. (*Co-first authors)
18. Bush, J. O., Lan, Y., Maltby, K. M., and Jiang, R. (2002).  Isolation and developmental expression analysis of Tbx22, the mouse homolog of the human X-linked cleft palate gene.  Developmental Dynamics 225:322-326.
19. Krebs, L. T., Iwai, N., Nonaka, S., Welsh, I. C., Lan, Y., Jiang, R., Saijoh, Y., O’Brien, T. P., Hamada, H., and Gridley, T. (2003).  Notch signaling regulates left-right asymmetry determination by inducing Nodal expression.  Genes & Development 17:1207-1212.
20. Bush, J. O., Maltby, K. M., Cho, E.-S., and Jiang, R. (2003).  The T-box gene Tbx10 exhibits a uniquely restricted expression pattern during mouse embryogenesis.  Gene Expression Patterns (Mechanisms of Development) 3:533-538.
21. Lan, Y., Ovitt, C. E., Cho, E.-S., Maltby, K. M., Wang, Q., and Jiang, R. (2004).  Odd-skipped related 2 (Osr2) encodes a key intrinsic regulator of secondary palate growth and morphogenesis. Development 131:3207-3216.
22. Bush, J. O., Lan, Y., and Jiang, R. (2004). The cleft lip and palate defects in the Dancer mutant mice result from gain of function of the Tbx10 gene. Proceedings of the National Academy of Sciences USA 101:7022-7027.
23. Hadland, B. K., Huppert, S., Kanungo, J., Xue, Y., Jiang, R., Gridley, T., Colon, R. A., Cheng, A. M., Kopan, R. and Longmore, G. D. (2004).  A requirement for Notch1 distinguishes two phases of definitive hematopoiesis during development.  Blood 104:3097-3105.
24. Alappat, S. R., Zhang, Z., Suzuki, K., Zhang, X., Jiang, R., Yamada, G. and Chen, Y. (2005).  The cellular and molecular etiology of cleft secondary palate in Fgf10 mutant mice.  Developmental Biology 277:102-113.
25. Knight, A. S., Schutte, B. C., Jiang, R. and Dixon, M. J. (2005).  Developmental expression analysis of the mouse and chick orthologues of IRF6: the gene mutated in Van der Woude syndrome.  Developmental Dynamics 235:1441-1447.
26. Wang, Q., Lan, Y., Cho, E.-S., Maltby, K. M. and Jiang, R. (2005).  Odd-skipped related 1 (Odd1) is an essential regulator of heart and urogenital development.  Developmental Biology 288:582-594.
27. Vieira, A.R., Avila, J. R., Daack-Hirsch, S., Dragan, E., Felix, T. M., Rahimov, F., Harrington, J., Schultz, R.R., Watanabe, Y., Johnson, M., Fang, J., O’Brien, S.E., Orioli, I.M., Castilla, E.E., FitzPatrick, D.R., Jiang, R., Marazita, M.L. and Murray, J.C. (2005).  Direct sequencing of candidate genes for nonsyndromic cleft lip and palate.  PLOS Genetics 1:e64.
28. Jiang, R., Bush, J. O. and Lidral, A. C. (2006).  Development of the upper lip: morphogenetic and molecular mechanisms.  Developmental Dynamics 235:1152-1166 (RJ is first and corresponding author for this review article).
29. Liu, H., Liu, W., Maltby, K. M., Lan, Y. and Jiang, R. (2006). Identification and developmental expression analysis of a novel homeobox gene closely linked to the mouse Twirler mutation.  Gene Expression Patterns (Mechanisms of Development) 6:632-636.
30. Lan, Y., Ryan, R. C., Zhang, Z., Bush, J. O., Maltby, K. M., Bullard, S. A., Lidral, A. C. and Jiang, R. (2006).  Expression of Wnt9b and activation of canonical Wnt signaling during midfacial morphogenesis in mice.  Developmental Dynamics 235:1448-1454.
31. Casey, L. M., Lan, Y., Cho, E.-S., Maltby, K. M., Gridley, T. and Jiang, R. (2006). Jag2-Notch1 signaling regulates oral epithelial differentiation and palate development.  Developmental Dynamics 235:1830-1844.
32. James, R.G., Kamei, C.N., Wang, Q., Jiang, R., and Schultheiss, T.M. (2006) Odd-skipped related 1 is required for development of the metanephric kidney and regulates formation and differentiation of kidney precursor cells. Development 15:2995-3004.
33. Chen, J., Bush, J.O., Ovitt, C.E., Lan, Y. and Jiang, R. (2007). The TGF-beta pseudoreceptor gene Bambi is dispensable for mouse embryonic development and postnatal survival.  Genesis 45:482-486.
34. Lan, Y., Wang, Q., Ovitt, C. E., and Jiang, R. (2007). A unique mouse strain expressing Cre recombinase for tissue-specific analysis of gene function in palate and kidney development. Genesis 45:618-624.
35. Liu, W., Lan, Y., Pauws, E., Meester-Smoor, M.A., Stanier, P., Zwarthoff, E.C., Jiang, R. (2008). The Mn1 transcription factor acts upstream of Tbx22 and preferentially regulates posterior palate growth in mice.  Development 135:3959-3968.
36. Gao, Y., Lan, Y., Ovitt, C.E., Jiang, R. (2009). Functional equivalence of the zinc finger transcription factors Osr1 and Osr2 in mouse development. Developmental Biology, in press.
37. Zhang, Z., Lan, Y., Chai, Y., and Jiang, R. (2009). Antagonistic actions of Msx1 and Osr2 pattern mammalian teeth into single row. Science 323:1232-1234.
38. Lan, Y., Jiang, R. (2008). Sonic hedgehog signaling regulates reciprocal epithelial-mesenchymal interactions controlling palatal outgrowth. Development, in press.
39. Richardson, R., Dixon, J., Jiang, R., Dixon, M. (2009). Integration of IRF6 and Jagged2 signaling is essential for controlling palatal adhesion and fusion competence. Human Molecular Genetics, in press.
40. Xiong W, He F, Morikawa Y, Yu X, Zhang ZY, Lan Y, Jiang R, Cserjesi P, Chen Y (2009). Hand2 is required in the epithelium for palatogenesis in mice. Developmental Biology, under revision.