生物通报道:来自中科院上海生命科学研究院生物化学与细胞生物学研究所,干细胞生物重点实验室(Key Laboratory of Stem Cell Biology),日本福井大学(Fukui University)医学院,美国Sloan-Kettering癌症研究中心(Memorial Sloan-Kettering Cancer Center ,MSKCC)等处的研究人员发现在神经发育早期,bHLH家族负性转录因子Id蛋白可以通过维持同家族中另一个转录因子Hes1基因的表达,抑制神经干细胞提前分化为神经元,从而使胚胎神经干细胞的数量维持在适当的水平,这揭示了神经发育早期神经干细胞维持的新机制。这一研究成果公布在《Developmental Cell》杂志上。
原文摘要: Developmental Cell, Vol 13, 283-297, 07 August 2007 Id Sustains Hes1 Expression to Inhibit Precocious Neurogenesis by Releasing Negative Autoregulation of Hes1 [Abstract]
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